The VarQ WebServer is built around a collection of available structural analysis tools tied together with the help of the workflow system Ruffus. Having as unique input an UniProt accession code and a list of variants to be analyzed, the pipeline performs several calculations to tag those variants, helping the user to interpret its effect over the protein structure.
You will find detailed information in our tutorials, this is an overview of the VarQ computational pipeline :
Tutorials and examples
Tutorial: Job loading instructions.
Tutorial: Explained output.
Help: Interpreting results.
NRAS: GTPase NRas
HRAS: GTPase HRas
KRAS: GTPase KRas
BRAF: Serine/threonine-protein kinase B-raf
RAF1: proto-oncogene serine/threonine-protein kinase
RASA1: Ras GTPase-activating protein 1
MAP2K1: Dual specificity mitogen-activated protein kinase kinase 1
MAP2K2: Dual specificity mitogen-activated protein kinase kinase 2
PTPN11: Tyrosine-protein phosphatase non-receptor type 11
SOS1: Son of sevenless homolog 1
SPRED1: Sprouty-related, EVH1 domain-containing protein 1