How to run a new Job?
First of all, click on the "New Job" button:
A screen to define your job parameters will be opened. Define there the UniProt accession of your target protein (mandatory).
Then if you want to search mutations in public databases(Be aware that widely studied proteins have hundred of reported mutations and some of the jobs very slow) and/or define specific mutations to be analyzed (up to 10 per job).
Tutorials and examples
Tutorial: Job loading instructions.
Tutorial: Explained output.
Help: Interpreting results.
NRAS: GTPase NRas
HRAS: GTPase HRas
KRAS: GTPase KRas
BRAF: Serine/threonine-protein kinase B-raf
RAF1: proto-oncogene serine/threonine-protein kinase
RASA1: Ras GTPase-activating protein 1
MAP2K1: Dual specificity mitogen-activated protein kinase kinase 1
MAP2K2: Dual specificity mitogen-activated protein kinase kinase 2
PTPN11: Tyrosine-protein phosphatase non-receptor type 11
SOS1: Son of sevenless homolog 1
SPRED1: Sprouty-related, EVH1 domain-containing protein 1