When the user specifies an UniProt accession to be analyzed, the VarQ Pipeline searches within all the available structures those that covers different segments of the sequence, preferring those with more coverage first and those with best resolution in second place as tiebreaker. Only those crystals covering at least 20 aminoacids of the sequence of the target protein are considered. If there are more than one crystal structure covering the same part of the protein sequence but they only differ in the fact that they have been crystallized with different ligands or cofactors all of them will be considered and will be shown in the list of results, since could be representing distinct conformational states of the protein. If the same protein is crystallized in complex with another protein it will be considered separately and will appear with the information of the partner protein. The UniProt database is requested online to list all the crystals available, so each job considers all PDBs present in the protein PDB database linked by the UniProt database in the day of the run.